We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nosocomial viral ventilator-associated pneumonia in the intensive care unit: a prospective cohort study.
- Authors
Daubin, Cédric; Vincent, Sophie; Vabret, Astrid; du Cheyron, Damien; Parienti, Jean-Jacques; Ramakers, Michel; Freymuth, François; Charbonneau, Pierre; Daubin, Cédric; Freymuth, François
- Abstract
<bold>Objective: </bold>To determine the incidence, risk factors, and clinical relevance of viral ventilator-associated pneumonia (VAP) in an adult intensive care unit (ICU).<bold>Design: </bold>Prospective observational study.<bold>Setting: </bold>A 22-bed adult medical ICU in a university hospital.<bold>Patients: </bold>All consecutive adult patients ventilated more than 48 h in a 9-month period including regular seasonal viral infections.<bold>Interventions: </bold>A tracheobronchial aspirate upon enrollment and at the time of VAP suspicion.<bold>Measurements and Results: </bold>All respiratory specimens were tested in culture, indirect immunofluorescence assay, and PCR or RT-PCR for virological assessment. Patients were followed until ICU discharge or death. One hundred thirty-nine patients were included. Upon enrollment, a respiratory virus was detected in the tracheobronchial aspirate in 25% of patients (35 of 139). The incidence of VAP, defined according to clinical daily evaluation, was 28% (39 of 139 patients). A bacteria was documented in 74% of cases, whereas no case of a causative viral infection was encountered among VAP patients; however, herpes simplex virus type-1 (HSV 1) infection was detected in respiratory specimens of 31% of VAP (12 of 39).<bold>Conclusions: </bold>We found a high incidence of HSV-1 infection in VAP patients; however, nosocomial viral VAP is likely to be rare in ICU, as assessed by the absence of respiratory virus-induced VAP identified in this prospective cohort study.
- Subjects
FRANCE; PNEUMONIA; INTENSIVE care units; NOSOCOMIAL infections; VIRUS diseases; MECHANICAL ventilators; IMMUNOFLUORESCENCE; ACADEMIC medical centers; CROSS infection; DNA viruses; LONGITUDINAL method; MULTIVARIATE analysis; POLYMERASE chain reaction; RNA viruses; TIME; VIRAL pneumonia; DISEASE incidence; REVERSE transcriptase polymerase chain reaction; MEDICAL equipment contamination
- Publication
Intensive Care Medicine, 2005, Vol 31, Issue 8, p1116
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-005-2706-1