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- Title
Bezlotoxumab.
- Authors
Johnson, Stuart; Gerding, Dale N
- Abstract
Clostridium difficile infection (CDI) is mediated by actions of toxin A and toxin B. Fully human monoclonal antibodies directed against the binding domains of these toxins were developed. Despite preclinical studies suggesting efficacy for the anti–toxin A monoclonal, actoxumab, the anti–toxin B monoclonal, bezlotoxumab, alone was shown to be effective in clinical trials. Intravenous infusion of bezlotoxumab at a 10 mg/kg dosage as adjunctive treatment reduced the risk of recurrent CDI over placebo for adult patients at increased risk for CDI recurrence in 2 large randomized, double-blind trials. Significant benefit was noted for patients with 1 or more of the following predefined risks: age >65 years, history of CDI, immunocompromise, severe CDI. Overall, bezlotoxumab appeared to be safe; however, an unexplained increased risk of heart failure was noted for patients with underlying congestive heart failure. Further refinement of who would benefit most and when best to administer bezlotoxumab is warranted.
- Subjects
THERAPEUTIC use of monoclonal antibodies; HEART failure risk factors; DISEASE relapse; INTRAVENOUS therapy; MONOCLONAL antibodies; CLOSTRIDIUM diseases; RANDOMIZED controlled trials; TREATMENT effectiveness; DISEASE risk factors; PREVENTION
- Publication
Clinical Infectious Diseases, 2019, Vol 68, Issue 4, p699
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciy577