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- Title
Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins
- Authors
Zafra, Delia; Nocito, Laura; Domínguez, Jorge; Guinovart, Joan J.
- Abstract
Abstract: Tungstate treatment ameliorates experimental diabetes by increasing liver glycogen deposition through an as yet unidentified mechanism. The signalling mechanism of tungstate was studied in CHOIR cells and primary cultured hepatocytes. This compound exerted its pro-glycogenic effects through a new G-protein-dependent and Tyr-Kinase Receptor-independent mechanism. Chemical or genetic disruption of G-protein signalling prevented the activation of the Ras/ERK cascade and the downstream induction of glycogen synthesis caused by tungstate. Thus, these findings unveil a novel non-canonical signalling pathway that leads to the activation of glycogen synthesis and that could be exploited as an approach to treat diabetes.
- Subjects
GLYCOGEN synthesis; G proteins; STREPTOZOTOCIN; PROTEIN kinase B; PERTUSSIS toxin; TREATMENT of diabetes
- Publication
FEBS Letters, 2013, Vol 587, Issue 3, p291
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.11.034