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- Title
Dietary exposure of mink ( Mustela vison) to fish from the upper Hudson River, New York, USA: Effects on organ mass and pathology.
- Authors
Bursian, Steven J.; Kern, John; Remington, Richard E.; Link, Jane E.; Fitzgerald, Scott D.
- Abstract
The authors evaluated effects of feeding ranch mink ( Mustela vison) diets containing polychlorinated biphenyl (PCB)-contaminated fish from the upper Hudson River (New York, USA) on adult and offspring organ mass and pathology. Diets contained 2.5 to 20% Hudson River fish, providing 0.72 to 6.1 µg ΣPCBs/g feed (4.8-38 pg toxic equivalents [TEQWHO 2005]/g feed). Absolute thyroid and adrenal gland masses were increased in adult females and 31-week-old juveniles, respectively, and absolute liver and heart masses were decreased in six-week-old kits exposed to dietary PCBs. Dietary concentrations of 0.72 µg ΣPCBs/g feed (4.8 pg TEQWHO 2005/g feed) and greater induced mandibular and maxillary squamous epithelial proliferation in adult animals. The dietary concentration of ΣPCBs predicted to result in 20% incidence of the jaw lesion (EC20) was 2.3 µg ΣPCBs/g feed (15 pg TEQWHO 2005/g feed), and the hepatic concentration was 2.8 µg ΣPCBs/g liver (89 pg TEQWHO 2005/g liver). The EC20 values were greater than the dietary and hepatic concentrations predicted to result in a 20% increase in kit mortality (LC20) at six weeks of age (0.34 µg ΣPCBs/g feed or 2.6 pg TEQWHO 2005/g feed and 0.80 µg ΣPCBs/g liver or 13 pg TEQWHO 2005/g liver). However, the EC20 values reflect exposure of adults to PCBs for approximately six months, and the LC20 values reflect exposure of offspring from conception onward. Environ. Toxicol. Chem. 2013;32:794-801. © 2013 SETAC
- Subjects
HUDSON River (N.Y. &; N.J.); MINKS -- Feeding &; feeds; POLYCHLORINATED biphenyls; PATHOLOGY; RANCHES
- Publication
Environmental Toxicology & Chemistry, 2013, Vol 32, Issue 4, p794
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1002/etc.2114