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- Title
Electrochemical DNA sensors.
- Authors
Drummond, T. Gregory; Hill, Michael G.; Barton, Jacqueline K.
- Abstract
Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical sensors exploit a range of different chemistries, but all take advantage of nanoscale interactions between the target in solution, the recognition layer and a solid electrode surface. Numerous approaches to electrochemical detection have been developed, including direct electrochemistry of DNA, electrochemistry at polymer-modified electrodes, electrochemistry of DNA-specific redox reporters, electrochemical amplifications with nanoparticles, and electrochemical devices based on DNA-mediated charge transport chemistry.
- Subjects
NUCLEOTIDE sequence; BIOELECTROCHEMISTRY; BIOSENSORS
- Publication
Nature Biotechnology, 2003, Vol 21, Issue 10, p1192
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt873