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- Title
A Case Report of Acute Renal Failure as a Result of Light-Chain-Mediated Acute Tubular Interstitial Nephritis in a 30-Year-Old Combat Veteran.
- Authors
Forster, Benjamin M.; Hinton, Adrian P.; Thurlow, John S.
- Abstract
We present a 30-year-old combat veteran with an unclear exposure history, with multiple deployments who was later diagnosed with acute renal failure as a result of light-chain deposition disease. Despite a drastic decline in kappa light chains following chemotherapy; his renal function worsened, and he progressed to end-stage renal disease, requiring hemodialysis. Light-chain-mediated acute tubular interstitial nephritis is an uncommon type of monoclonal gammopathy of renal significance presenting with acute renal failure without significant glomerular disease. Our case illustrates that light-chain-mediated acute tubular interstitial nephritis may present clinically like acute interstitial nephritis and that renal biopsy is critical for diagnosis. We also explore possible links between various environmental and occupational exposures that could have precipitated his disease process at such a young age.
- Subjects
UNITED States; ACUTE kidney failure; INTERSTITIAL nephritis; MEDICAL care of veterans; POST-traumatic stress disorder; MULTIPLE myeloma; IMMUNOLOGICAL deficiency syndrome complications; KIDNEY injuries; KIDNEYS; BLACK people; HEPATITIS C; IMMUNOGLOBULINS; VETERANS; UNITED States. Dept. of Veterans Affairs; DISEASE complications; ANATOMY
- Publication
Military Medicine, 2017, Vol 182, Issue 11, pe2099
- ISSN
0026-4075
- Publication type
journal article
- DOI
10.7205/MILMED-D-17-00164