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- Title
Impact of total radiotherapy dose on survival for head and neck Merkel cell carcinoma after resection.
- Authors
Patel, Sagar A.; Qureshi, Muhammad M.; Mak, Kimberley S.; Sahni, Debjani; Giacalone, Nicholas J.; Ezzat, Waleed; Jalisi, Scharukh; Truong, Minh Tam
- Abstract
Background Head and neck Merkel cell carcinoma (MCC) is commonly treated with surgery and adjuvant radiotherapy (RT) for high-risk features. The optimal radiation dose is unknown. Methods One thousand six hundred twenty-five eligible patients with head and neck MCC were identified in the National Cancer Data Base (NCDB). Radiation dose was divided into 3 groups: 30 to <50 Gray (Gy), 50-55 Gy, and >55-70 Gy. Cox regression was used to compare overall survival (OS) between groups, accounting for age, sex, stage, surgery type, margin status, comorbidities, and use of chemotherapy. Results With a median follow-up of 33.5 months, 3-year OS was 48.9%, 70.3%, and 58.7% for 30 to <50 Gy, 50-55 Gy, and >55-70 Gy, respectively ( P < .001). Compared to 50-55 Gy, doses between 30 to <50 Gy (adjusted hazard ratio [HR] 1.53; 95% confidence interval [CI] 1.17-1.99; P = .002) and >55-70 Gy (adjusted HR 1.21; 95% CI 1.0-1.46; P = .06) were associated with worse survival. Conclusion Adjuvant radiation doses within 50-55 Gy may be optimal for head and neck MCC.
- Subjects
MERKEL cell carcinoma; HEAD &; neck cancer; RADIOTHERAPY; CANCER chemotherapy; ADJUVANT treatment of cancer
- Publication
Head & Neck, 2017, Vol 39, Issue 7, p1371
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24776