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- Title
Establishment of left–right asymmetry in vertebrate development: the node in mouse embryos.
- Authors
Komatsu, Yoshihiro; Mishina, Yuji
- Abstract
Establishment of vertebrate left–right asymmetry is a critical process for normal embryonic development. After the discovery of genes expressed asymmetrically along the left–right axis in chick embryos in the mid 1990s, the molecular mechanisms responsible for left–right patterning in vertebrate embryos have been studied extensively. In this review article, we discuss the mechanisms by which the initial symmetry along the left–right axis is broken in the mouse embryo. We focus on the role of primary cilia and molecular mechanisms of ciliogenesis at the node when symmetry is broken and left–right asymmetry is established. The node is considered a signaling center for early mouse embryonic development, and the results we review here have led to a better understanding of how the node functions and establishes left–right asymmetry.
- Subjects
VERTEBRATE development; MICE embryology; GENE expression; CELL cycle; GROWTH factors; CILIA &; ciliary motion; CELLULAR signal transduction
- Publication
Cellular & Molecular Life Sciences, 2013, Vol 70, Issue 24, p4659
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-013-1399-9