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- Title
SQSTM1 Gene Analysis and Gene-Environment Interaction in Paget's Disease of Bone.
- Authors
Gennari, Luigi; Gianfrancesco, Fernando; Di Stefano, Marco; Rendina, Domenico; Merlotti, Daniela; Esposito, Teresa; Gallone, Salvatore; Fusco, Pina; Rainero, Innocenzo; Fenoglio, Pierpaola; Mancini, Maria; Martini, Giuseppe; Bergui, Simona; De Filippo, Gianpaolo; Isaia, Giancarlo; Strazzullo, Pasquale; Nuti, Ranuccio; Mossetti, Giuseppe
- Abstract
The article presents a study that analyzed SQSTM1 mutations in patients afflicted with Paget's disease of bone (PDB) in the high-incidence area of Campania, Italy. The results of the study showed that patients from Campania had the highest incidence of contact with animals while a decrease in the prevalence of animal contacts related to age and a parallel increase in the incidents of SQSTM1 mutations were noted. The data suggest the importance of animal-related factors to the etiology of PDB which interact with SQSTM1 mutations.
- Subjects
CAMPANIA (Italy); ITALY; GENETIC mutation; OSTEITIS deformans; ANIMALS
- Publication
Journal of Bone & Mineral Research, 2010, Vol 25, Issue 6, p1375
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.31