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- Title
Inflammatory immune responses by water-insoluble alpha-glucans.
- Authors
Okamoto S; Terao Y; Kaminishi H; Hamada S; Kawabata S; Okamoto, S; Terao, Y; Kaminishi, H; Hamada, S; Kawabata, S
- Abstract
Water-insoluble alpha-glucans are synthesized from sucrose by glucosyltransferase-I of mutans streptococci and play an important role in the development of dental plaque. Several types of beta-glucans in fungal cell wall components and water-soluble alpha-glucans from Streptococcus mutans are known to modulate innate immunity. In the present study, we investigated whether water-insoluble alpha-glucans also induced inflammatory innate immune responses. Our results showed that water-insoluble alpha-glucans synthesized by Streptococcus sobrinus activated mouse peritoneal exudate macrophages to produce pro-inflammatory cytokines. The immunological responses were not due to contamination by sucrose, water-soluble alpha-glucan, lipopolysaccharide, or peptidoglycan. Furthermore, human monocytes stimulated by water-insoluble alpha-glucans produced TNF-alpha and IL-8, while human polymorphonuclear cells were activated by water-insoluble alpha-glucans, resulting in chemotaxis and hydrogen peroxide production. The results demonstrated that water-soluble alpha-glucans modulate macrophage- and granulocyte-induced inflammatory immune responses, and suggest that inflammation induced by those alpha-glucans is associated with the development of periodontal diseases.
- Subjects
ANIMAL experimentation; CELL physiology; CELLS; CYTOKINES; GLUCANS; IMMUNITY; INFLAMMATORY mediators; MACROPHAGES; MICE; MONOCYTES; PROTEINS; SOLUBILITY; VIRIDANS strepotococci
- Publication
Journal of Dental Research, 2007, Vol 86, Issue 3, p242
- ISSN
0022-0345
- Publication type
journal article
- DOI
10.1177/154405910708600309