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- Title
The Association between the Level of Serum Interleukin-31 (II-31) and Interleukin-33 (11-33) and Pruritus in Patients with Allergic Diseases.
- Authors
Ashari, Noor Suryani Mohd; Amin, Siti Noor Syuhada Muhammad; Musa, Mustaffa; Hamid, Wan Zuraida Wan Ab; Rahman, Azriani Ab; Mohamad, Irfan
- Abstract
Objectives: This study was done to determine the association between IL-31 and IL-33 serum levels and pruritus in patients with allergic diseases. Design: This was a comparative cross sectional study. Methods: Allergic diseases patients including atopic dermatitis (AD), allergic rhinitis (AR) and atopic asthma (AA) attending Hospital Universiti Sains Malaysia (HUSM) and Hospital Raja Perempuan Zainab II (HRPZ II), Malaysia were defined by history taken by physician. 5 ml of blood was collected and analyzed for IL-31 and IL-33 using EL ISA kits (Human IL-31 and IL-33 Duoset, R&D System). One way ANOVA was used to compare the level of serum IL-31 and IL-33 between those with and without pruritus. Results: A total number of 210 allergic patients were included in this study. The results showed there was no significant difference in the mean level of IL-33 serum in non- pruritic (mean of 254.71, SD of 906.80) and in pruritic allergic patients (mean of 1219.61, SD of 8660.01, p = 0.156). There was also no significant difference in the mean level of IL-31 serum (p = 0.241). However, the level of IL-31 was higher in pruritic patients (mean of 6168.25; SD 30552.07) than in non-pruritic patients (mean of 3058.09, SD 12527.97). Conclusions: The results of this study suggest that there was no significant association between pruritus and the level of serum IL-31 and IL-33 in Malaysian allergic patients.
- Subjects
ALLERGIES; ENZYME-linked immunosorbent assay; INTERLEUKINS; ITCHING; ONE-way analysis of variance
- Publication
International Medical Journal, 2016, Vol 23, Issue 5, p526
- ISSN
1341-2051
- Publication type
Article