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- Title
Angiogenesis in Tumor Growth: A Review.
- Authors
Kabiraj, Arpita; Khaitan, Tanya; Bhattacharya, Preeti Tomar; Gupta, Jagriti; Malik, Shan Nawaz; Alam, Mohammad Khursheed
- Abstract
Background: Oral squamous cell carcinoma (OSCC) is a malignant neoplasm arising from the dysplastic epithelium of the oral cavity. It arises as a result of multiple molecular events that develop from the combined influences of an individual's genetic predisposition and exposure to environmental carcinogens. As OSCCs grow, invade and metastasize, new blood vessel formation is critical. OSCCs, like most tumors, are able to create a blood supply by stimulating endothelial cell proliferation and new blood vessel formation. Review summary: Angiogenesis, the growth of new blood vessels from pre-existing ones, is one of the essential phenotypes of tumor formation and it typically involves sprouting, branching and differential growth of pre-existing blood vessels, as well as the recruitment of supporting cells associated with the endothelium, including smooth muscle cells and pericytes. Tumor angiogenesis and the density of newly formed vessels are of potential prognostic relevance in the assessment of malignant neoplasia. Conclusion: Although the results of some clinical trials have been disappointing, a better understanding of the correct timing for the use of antiangiogenic drugs, the selection of patients that can really benefit from these treatments and the combination with cooperating conventional therapies will very likely place these agents among the most advanced anticancer strategies.
- Subjects
EPITHELIAL cells; SQUAMOUS cell carcinoma; PATHOLOGIC neovascularization
- Publication
International Medical Journal, 2016, Vol 23, Issue 5, p490
- ISSN
1341-2051
- Publication type
Article