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- Title
Generic Substitution Issues: Brand-generic Substitution, Generic-generic Substitution, and Generic Substitution of Narrow Therapeutic Index (NTI)/Critical Dose Drugs.
- Authors
Paveliu, Marian Sorin; Bengea, Simona; Paveliu, Fraga Silvia
- Abstract
Doctors accuse individual variability or lack of quality of generic drugs for adverse reactions or lack of efficacy. The variability of effect of generic substitution, although accepted by clinicians as possible, is little discussed or even understood by them. The situation is really serious in the case of generic substitution of drugs with narrow therapeutic index (NTI) or critical dose. In this paper we review the basic notions of variability and effectiveness of generic medication and change of attitude that would improve the use of these drugs.
- Subjects
GENERIC drugs; DRUG efficacy; GENERIC drug substitution; PHARMACEUTICAL arithmetic; DRUG side effects
- Publication
Maedica - a Journal of Clinical Medicine, 2011, Vol 6, Issue 1, p52
- ISSN
1841-9038
- Publication type
Article