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- Title
Serological Evidence of Human Infection With Avian Influenza A(H7N9) Virus: A Systematic Review and Meta-analysis.
- Authors
Wang, Wei; Chen, Xinhua; Wang, Yan; Lai, Shengjie; Yang, Juan; Cowling, Benjamin J; Horby, Peter W; Uyeki, Timothy M; Yu, Hongjie
- Abstract
<bold>Background: </bold>The extent of human infections with avian influenza A(H7N9) virus, including mild and asymptomatic infections, is uncertain.<bold>Methods: </bold>We performed a systematic review and meta-analysis of serosurveys for avian influenza A(H7N9) virus infections in humans published during 2013-2020. Three seropositive definitions were assessed to estimate pooled seroprevalence, seroconversion rate, and seroincidence by types of exposures. We applied a scoring system to assess the quality of included studies.<bold>Results: </bold>Of 31 included studies, pooled seroprevalence of A(H7N9) virus antibodies from all participants was 0.02%, with poultry workers, close contacts, and general populations having seroprevalence of 0.1%, 0.2%, and 0.02%, respectively, based on the World Health Organization (WHO)-recommended definition. Although most infections were asymptomatic, evidence of infection was highest in poultry workers (5% seroconversion, 19.1% seroincidence per 100 person-years). Use of different virus clades did not significantly affect seroprevalence estimates. Most serological studies were of low to moderate quality and did not follow standardized seroepidemiological protocols or WHO-recommended laboratory methods.<bold>Conclusions: </bold>Human infections with avian influenza A(H7N9) virus have been uncommon, especially for general populations. Workers with occupational exposures to poultry and close contacts of A(H7N9) human cases had low risks of infection.
- Subjects
CHINA; AVIAN influenza epidemiology; BIRDS; RESEARCH; FERRANS &; Powers Quality of Life Index; INFLUENZA A virus; POULTRY; META-analysis; ANIMAL experimentation; RESEARCH methodology; SYSTEMATIC reviews; EVALUATION research; COMPARATIVE studies; INFLUENZA; QUESTIONNAIRES; RESEARCH funding; EPIDEMIOLOGICAL research
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 1, p70
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa679