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- Title
Chronic rhinosinusitis endotypes associate with distinct local cytokine milieus that shape the distribution of innate lymphoid cells.
- Authors
Ko, Young Gyun; Kim, Min Ho; Park, Joo Yong; Gil, Chan Hee; Kim, Tae Soo; Choi, Ji‐Yeob; Chung, Doo Hyun; Kim, Hyun Jik; Kim, Dong Young; Kim, Hye Young
- Abstract
Flow cytometry served to determine the frequencies of ILC subsets (A-C, G) and total ILCs expressing signature ILC-subset cytokines (D-E) in the CD45+ cells from control-UTs, CRSsNP-UTs, CRSwNP-UTs, and CRSwNP-NPs (A-E) or ECRS-NPs and NECRS-NPs (G, H). Similar transcriptome comparisons with NPs from ECRS and NECRS patients using our data and a public database (GSE72713)5 then showed that ECRS and NECRS clustered separately. There were 28 ECRS-NPs and eight NECRS-NPs in (G) and (H) and 39 control-UTs in (H).
- Subjects
INNATE lymphoid cells; NASAL polyps; SINUSITIS; THYMIC stromal lymphopoietin; CYTOKINES; TYPE I interferons; ENDOSCOPIC surgery
- Publication
Allergy, 2022, Vol 77, Issue 7, p2246
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15300