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- Title
Group 2 innate lymphoid cells in patients with nonasthmatic eosinophilic bronchitis.
- Authors
Zhan, Chen; Liu, Jiaxing; Li, Bizhou; Xu, Rong; Liang, Wanqin; Zhang, Shengfang; Fang, Liman; Zhong, Shuxin; Shaniya Helen de Silva, S. Dushinka; Sivapalan, Dhinesan; Luo, Wei; Wang, Hongyu; Li, Jing; Lai, Kefang; Zhong, Nanshan; Sehmi, Roma; O'Byrne, Paul M; Chen, Ruchong
- Abstract
In line with a previous study, we found elevated levels of sputum CD4 SP + sp CRth2 SP + sp T cells compared with HC (Figure 1A; Table S2), suggesting a role for Th2 cells in driving airway eosinophilia in NAEB. Steroid treatment is reported to increase ILC2s cell death, reduce capacity for cell proliferation, and cell trans-differentiation. Brightling CE et al2 reported that NAEB patients had increased proportion of interleukin (IL)-4 SP + sp CD4 SP + sp T cells in bronchoalveolar lavage fluid, suggesting the role of Th2 cells in NAEB.
- Subjects
INNATE lymphoid cells; COUGH; PULMONARY eosinophilia; BRONCHITIS; TH2 cells
- Publication
Allergy, 2022, Vol 77, Issue 2, p649
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15068