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SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification.
Published in:
2021
By:
- Calcagno, David M.;
- Zhang, Claire;
- Toomu, Avinash;
- Kenneth Huang;
- Ninh, Van K.;
- Shigeki Miyamoto;
- Aguirre, Aaron D.;
- Zhenxing Fu;
- Brown, Joan Heller;
- King, Kevin R.;
- Huang, Kenneth;
- Miyamoto, Shigeki;
- Fu, Zhenxing;
- Heller Brown, Joan
Publication type:
journal article
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Published in:
2009
By:
- Ling, Haiyun;
- Zhang, Tong;
- Pereira, Laetitia;
- Means, Christopher Kable;
- Cheng, Hongqiang;
- Gu, Yusu;
- Dalton, Nancy D.;
- Peterson, Kirk L.;
- Chen, Ju;
- Bers, Donald;
- Heller^Brown, Joan;
- Brown, Joan Heller
Publication type:
journal article
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice.
Published in:
2008
By:
- Sheikh, Farah;
- Raskin, Anna;
- Chu, Pao-Hsien;
- Lange, Stephan;
- Domenighetti, Andrea A.;
- Zheng, Ming;
- Liang, Xingqun;
- Zhang, Tong;
- Yajima, Toshitaka;
- Gu, Yusu;
- Dalton, Nancy D.;
- Mahata, Sushil K.;
- Dorn II, Gerald W.;
- Heller-Brown, Joan;
- Peterson, Kirk L.;
- Omens, Jeffrey H.;
- McCulloch, Andrew D.;
- Chen, Ju;
- Dorn, Gerald W 2nd;
- Brown, Joan Heller
Publication type:
journal article
Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling.
Published in:
PLoS Biology, 2020, v. 18, n. 9, p. 1, doi. 10.1371/journal.pbio.3000866
By:
- Zhang, Jason Z.;
- Nguyen, Andy H.;
- Miyamoto, Shigeki;
- Heller Brown, Joan;
- McCulloch, Andrew D.;
- Zhang, Jin
Publication type:
Article
Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.
Published in:
2017
By:
- Dusaban, Stephanie S.;
- Chun, Jerold;
- Rosen, Hugh;
- Purcell, Nicole H.;
- Brown, Joan Heller
Publication type:
journal article
CaMKIIδ splice variants exert differential effects on heart failure development and myocardial ischemia/reperfusion injury (652.14).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.652.14
By:
- Gray, Charles;
- Xiang, Sunny;
- Mishra, Shikha;
- Heller Brown, Joan
Publication type:
Article
Phospholipase C‐epsilon links G‐protein coupled receptor activation to inflammatory responses in astrocytes (1066.5).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.1066.5
By:
- Dusaban, Stephanie;
- Purcell, Nicole;
- Kunkel, Maya;
- Smrcka, Alan;
- Heller Brown, Joan
Publication type:
Article
GPCRs are regulators of MRTF‐A and YAP mediated CCN1 expression (1066.4).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.1066.4
By:
- Yu, Olivia;
- Miyamoto, Shigeki;
- Heller Brown, Joan
Publication type:
Article
Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.
Published in:
FASEB Journal, 2008, v. 22, n. 11, p. 4011, doi. 10.1096/fj.08-113266
By:
- Walsh, Colin T.;
- Radeff-Huang, Julie;
- Matteo, Rosalia;
- Hsiao, Albert;
- Subramaniam, Shankar;
- Stupack, Dwayne;
- Brown, Joan Heller
Publication type:
Article
G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival.
Published in:
Journal of Cellular Biochemistry, 2004, v. 92, n. 5, p. 949, doi. 10.1002/jcb.20094
By:
- Julie Radeff‐Huang;
- Tammy M. Seasholtz;
- Rosalia G. Matteo;
- Joan Heller Brown
Publication type:
Article
Akt regulates L-type Ca2+ channel activity by modulating Cavα 1 protein stability.
Published in:
Journal of Cell Biology, 2009, v. 184, n. 6, p. 923, doi. 10.1083/jcb.200805063
By:
- Catalucci, Daniele;
- Deng-Hong Zhang;
- DeSantiago, Jaime;
- Aimond, Franck;
- Barbara, Guillaume;
- Chemin, Jean;
- Bonci, Désiré;
- Picht, Eckard;
- Rusconi, Francesca;
- Dalton, Nancy D.;
- Peterson, Kirk L.;
- Richard, Sylvain;
- Bers, Donald M.;
- Brown, Joan Heller;
- Condorelli, Gianluigi
Publication type:
Article
PLCε, PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart.
Published in:
Science Signaling, 2013, v. 6, n. 306, p. 1, doi. 10.1126/scisignal.2004405
By:
- Xiang, Sunny Y.;
- Kunfu Ouyang;
- Yung, Bryan S.;
- Shigeki Miyamoto;
- Smrcka, Alan V.;
- Ju Chen;
- Brown, Joan Heller
Publication type:
Article
Differences and Similarities in Muscarinic Receptors of Rat Heart and Retina: Effects of Agonists, Guanine Nucleotides, and N-Ethylmaleimide.
Published in:
Journal of Neurochemistry, 1984, v. 43, n. 1, p. 214, doi. 10.1111/j.1471-4159.1984.tb06699.x
By:
- Dunlap, Janet;
- Brown, Joan Heller
Publication type:
Article
CaMKII confirms its promise in ischaemic heart disease.
Published in:
European Journal of Heart Failure, 2014, v. 16, n. 12, p. 1268, doi. 10.1002/ejhf.204
By:
- van Oort, Ralph J.;
- Brown, Joan Heller;
- Westenbrink, B. Daan
Publication type:
Article
APJ acts as a dual receptor in cardiac hypertrophy.
Published in:
Nature, 2012, v. 488, n. 7411, p. 394, doi. 10.1038/nature11263
By:
- Scimia, Maria Cecilia;
- Hurtado, Cecilia;
- Ray, Saugata;
- Metzler, Scott;
- Wei, Ke;
- Wang, Jianming;
- Woods, Chris E.;
- Purcell, Nicole H.;
- Catalucci, Daniele;
- Akasaka, Takeshi;
- Bueno, Orlando F.;
- Vlasuk, George P.;
- Kaliman, Perla;
- Bodmer, Rolf;
- Smith, Layton H.;
- Ashley, Euan;
- Mercola, Mark;
- Brown, Joan Heller;
- Ruiz-Lozano, Pilar
Publication type:
Article
Decline in cellular function of aged mouse c-kit+ cardiac progenitor cells.
Published in:
Journal of Physiology, 2017, v. 595, n. 19, p. 6249, doi. 10.1113/JP274775
By:
- Castaldi, Alessandra;
- Dodia, Ramsinh Mansinh;
- Orogo, Amabel M.;
- Zambrano, Cristina M.;
- Najor, Rita H.;
- Gustafsson, Åsa B.;
- Heller Brown, Joan;
- Purcell, Nicole H.
Publication type:
Article
Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes.
Published in:
Journal of Physiology, 2014, v. 592, n. 5, p. 971, doi. 10.1113/jphysiol.2013.264697
By:
- Zhang, Dai‐Min;
- Chai, Yongping;
- Erickson, Jeffrey R.;
- Brown, Joan Heller;
- Bers, Donald M.;
- Lin, Yu‐Fung
Publication type:
Article
Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-49164-4
By:
- Chaim, Olga Meiri;
- Miki, Shunichiro;
- Prager, Briana C.;
- Ma, Jianhui;
- Jeong, Anthony Y.;
- Lara, Jacqueline;
- Tran, Nancy K.;
- Smith, Jeffrey M.;
- Rich, Jeremy N.;
- Gutkind, J. Silvio;
- Miyamoto, Shigeki;
- Furnari, Frank B.;
- Brown, Joan Heller
Publication type:
Article
Identification of Potential Small Molecule Binding Pockets on Rho Family GTPases.
Published in:
PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040809
By:
- Ortiz-Sanchez, Juan Manuel;
- Nichols, Sara E.;
- Sayyah, Jacqueline;
- Brown, Joan Heller;
- Andrew McCammon, J.;
- Grant, Barry J.
Publication type:
Article
Novel Allosteric Sites on Ras for Lead Generation.
Published in:
PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0025711
By:
- Grant, Barry J.;
- Lukman, Suryani;
- Hocker, Harrison J.;
- Sayyah, Jaqueline;
- Brown, Joan Heller;
- McCammon, J. Andrew;
- Gorfe, Alemayehu A.
Publication type:
Article
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis.
Published in:
European Heart Journal, 2011, v. 32, n. 17, p. 2179, doi. 10.1093/eurheartj/ehq496
By:
- Cheng, Zhaokang;
- Völkers, Mirko;
- Din, Shabana;
- Avitabile, Daniele;
- Khan, Mohsin;
- Gude, Natalie;
- Mohsin, Sadia;
- Bo, Tao;
- Truffa, Silvia;
- Alvarez, Roberto;
- Mason, Matt;
- Fischer, Kimberlee M.;
- Konstandin, Mathias H.;
- Zhang, Xiao-kun;
- Heller Brown, Joan;
- Sussman, Mark A.
Publication type:
Article
Influence of neuroleptic drugs and apomorphine on dopamine-sensitive adenylate cyclase of retina.
Published in:
Journal of Neurochemistry, 1973, v. 21, n. 2, p. 477, doi. 10.1111/j.1471-4159.1973.tb04268.x
By:
- Brown, Joan Heller;
- Makman, M. H.
Publication type:
Article
Ca2+/calmodulin‐dependent kinase IIδC‐induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak.
Published in:
ESC Heart Failure, 2024, v. 11, n. 4, p. 2191, doi. 10.1002/ehf2.14772
By:
- Dewenter, Matthias;
- Seitz, Tilmann;
- Steinbrecher, Julia H.;
- Westenbrink, B. Daan;
- Ling, Haiyun;
- Lehnart, Stephan E.;
- Wehrens, Xander H.T.;
- Backs, Johannes;
- Brown, Joan Heller;
- Maier, Lars S.;
- Neef, Stefan
Publication type:
Article
RGS16 inhibits signalling through the Ga13-Rho axis.
Published in:
Nature Cell Biology, 2003, v. 5, n. 12, p. 1095, doi. 10.1038/ncb1065
By:
- Druey, Kirk M.;
- Waheed, Abdul A.;
- Kreutz, Barry;
- Suzuki, Nobuchika;
- Kozasa, Tohru;
- Jones, Teresa L. Z.;
- Brown, Joan Heller;
- Seasholtz, Tammy M.;
- Johnson, Eric N.
Publication type:
Article
G-proteins in growth and apoptosis: lessons from the heart.
Published in:
Oncogene, 2001, v. 20, n. 13, p. 1626, doi. 10.1038/sj.onc.1204275
By:
- Adams, John W;
- Brown, Joan Heller
Publication type:
Article
The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain.
Published in:
Oncogene, 1997, v. 15, n. 5, p. 595, doi. 10.1038/sj.onc.1201220
By:
- Collins, Lila R;
- Ricketts, William A;
- Olefsky, Jerrold M;
- Brown, Joan Heller
Publication type:
Article
Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.
Published in:
Molecular Oncology, 2022, v. 16, n. 3, p. 607, doi. 10.1002/1878-0261.13128
By:
- Yu, Le;
- Zhou, Dan;
- Zhang, Guiming;
- Ren, Zhonglu;
- Luo, Xin;
- Liu, Peng;
- Plouffe, Steven W.;
- Meng, Zhipeng;
- Moroishi, Toshiro;
- Li, Yilei;
- Zhang, Yiyue;
- Brown, Joan Heller;
- Liu, Shuwen;
- Guan, Kun‐Liang
Publication type:
Article
Lipid signalling in cardiovascular pathophysiology.
Published in:
Cardiovascular Research, 2009, v. 82, n. 2, p. 171
By:
- Joel S. Karliner;
- Joan Heller Brown
Publication type:
Article
Sphingosine-1-phosphate receptor signalling in the heart.
Published in:
Cardiovascular Research, 2009, v. 82, n. 2, p. 193
By:
- Christopher K. Means;
- Joan Heller Brown
Publication type:
Article
Announcement: Spotlight Issue on Lipid Signalling Pathways in the Heart and Vasculature.
Published in:
Cardiovascular Research, 2008, v. 79, n. 3, p. NP, doi. 10.1093/cvr/cvn197
By:
- Karliner, Joel S.;
- Brown, Joan Heller
Publication type:
Article
Announcement: Spotlight Issue on Lipid Signalling Pathways in the Heart and Vasculature.
Published in:
Cardiovascular Research, 2008, v. 79, n. 2, p. NP, doi. 10.1093/cvr/cvn167
By:
- Karliner, Joel S.;
- Brown, Joan Heller
Publication type:
Article
Calmodulin and Ca2+/calmodulin kinases in the heart — Physiology and pathophysiology
Published in:
2007
By:
- Maier, Lars S.;
- Bers, Donald M.;
- Brown, Joan Heller
Publication type:
Editorial
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
Published in:
Cardiovascular Research, 2004, v. 63, n. 3, p. 476, doi. 10.1016/j.cardiores.2004.04.026
By:
- Zhang, Tong;
- Brown, Joan Heller
Publication type:
Article
Cardiomyocyte NLRP3 Contributes to the Cardiac Inflammatory Response.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.04727
By:
- Ninh, Van;
- Miyamoto, Shigeki;
- Heller Brown, Joan
Publication type:
Article
CCL2‐ Dependent Macrophage Recruitment by Glioblastoma Stem Cells: The Role of Gα12 and YAP Signaling.
Published in:
FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.04163
By:
- Chaim, Olga;
- Flores, Anabel;
- Heller Brown, Joan
Publication type:
Article
Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2.
Published in:
Journal of Neurochemistry, 2004, v. 91, n. 2, p. 501, doi. 10.1111/j.1471-4159.2004.02749.x
By:
- Seasholtz, Tammy M.;
- Radeff-Huang, Julie;
- Sagi, Sarah A.;
- Matteo, Rosalia;
- Weems, Jessica M.;
- Cohen, Annemarie Stoudt;
- Feramisco, James R.;
- Brown, Joan Heller
Publication type:
Article
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca 2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 9, p. 4427, doi. 10.3390/ijms22094427
By:
- Pavez-Giani, Mario G.;
- Sánchez-Aguilera, Pablo I.;
- Bomer, Nils;
- Miyamoto, Shigeki;
- Booij, Harmen G.;
- Giraldo, Paula;
- Oberdorf-Maass, Silke U.;
- Nijholt, Kirsten T.;
- Yurista, Salva R.;
- Milting, Hendrik;
- van der Meer, Peter;
- Boer, Rudolf A. de;
- Heller Brown, Joan;
- Sillje, Herman W. H.;
- Westenbrink, B. Daan;
- Acuña-Castroviejo, Darío
Publication type:
Article
RhoA protects the mouse heart against ischemia/reperfusion injury.
Published in:
2011
By:
- Sunny Yang Xiang;
- Vanhoutte, Davy;
- Del Re, Dominic P.;
- Purcell, Nicole H.;
- Haiyun Ling;
- Banerjee, Indroneal;
- Bossuyt, Julie;
- Lang, Richard A.;
- Yi Zheng;
- Matkovich, Scot J.;
- Miyamoto, Shigeki;
- Molkentin, Jeffery D.;
- Dorn II, Gerald W.;
- Brown, Joan Heller;
- Xiang, Sunny Yang;
- Ling, Haiyun;
- Zheng, Yi;
- Dorn, Gerald W 2nd
Publication type:
journal article
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.
Published in:
2010
By:
- Elrod, John W.;
- Wong, Renee;
- Mishra, Shikha;
- Vagnozzi, Ronald J.;
- Sakthievel, Bhuvana;
- Goonasekera, Sanjeewa A.;
- Karch, Jason;
- Gabel, Scott;
- Farber, John;
- Force, Thomas;
- Brown, Joan Heller;
- Murphy, Elizabeth;
- Molkentin, Jeffery D.
Publication type:
journal article
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.
Published in:
2010
By:
- Denghong Zhang;
- Contu, Riccardo;
- Latronico, Michael V. G.;
- Jian Ling Zhang;
- Rizzi, Roberto;
- Catalucci, Daniele;
- Miyamoto, Shigeki;
- Huang, Katherine;
- Ceci, Marcello;
- Yusu Gu;
- Dalton, Nancy D.;
- Peterson, Kirk L.;
- Guan, Kun-Liang;
- Brown, Joan Heller;
- Ju Chen;
- Sonenberg, Nahum;
- Condorelli, Gianluigi;
- Zhang, Denghong;
- Zhang, Jianlin;
- Zhang, Jian Ling
Publication type:
journal article
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death.
Published in:
2009
By:
- Diwan, Abhinav;
- Matkovich, Scot J.;
- Qunying Yuan;
- Wen Zhao;
- Yatani, Atsuko;
- Brown, Joan Heller;
- Molkentin, Jeffery D.;
- Kranias, Evangelia G.;
- Dorn, II, Gerald W.;
- Yuan, Qunying;
- Zhao, Wen;
- Dorn, Gerald W 2nd
Publication type:
journal article
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels.
Published in:
2006
By:
- Wagner, Stefan;
- Dybkova, Nataliya;
- Rasenack, Eva C. L.;
- Jacobshagen, Claudius;
- Fabritz, Larissa;
- Kirchhof, Paulus;
- Maier, Sebastian K. G.;
- Tong Zhang;
- Hasenfuss, Gerd;
- Brown, Joan Heller;
- Bers, Donald M.;
- Maier, Lars S.;
- Zhang, Tong
Publication type:
journal article
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.
Published in:
2006
By:
- Wu, Xu;
- Zhang, Tong;
- Bossuyt, Julie;
- Li, Xiaodong;
- McKinsey, Timothy A;
- Dedman, John R;
- Olson, Eric N;
- Chen, Ju;
- Brown, Joan Heller;
- Bers, Donald M
Publication type:
journal article
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.
Published in:
Journal of Clinical Investigation, 2006, v. 116, n. 3, p. 675, doi. 10.1172/JCI27374
By:
- Xu Wu;
- Tong Zhang;
- Bossuyt, Julie;
- Xiaodong Li;
- McKinsey, Timothy A.;
- Dedman, John R.;
- Olson, Eric N.;
- Ju Chen;
- Brown, Joan Heller;
- Bers, Donald M.
Publication type:
Article

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