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- Title
Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population.
- Authors
Awata, Takuya; Kurihara, Susumu; Iitaka, Makoto; Takei, Shin-ichiro; Inoue, Ikuo; Ishii, Chikara; Negishi, Kiyohiko; Izumida, Taro; Yoshida, Yoko; Hagura, Ryoko; Kuzuya, Nobuaki; Kanazawa, Yasunori; Katayama, Shigehiro; Awata, T; Kurihara, S; Iitaka, M; Takei, S; Inoue, I; Ishii, C; Negishi, K
- Abstract
Analyzes CTLA-4 gene polymorphism in Japanese patients with insulin-dependent diabetes mellitus or autoimmune thyroid disease (AITD). Determination of the A-G transition polymorphism at position 49 by polymerase chain reaction; Increase in the frequency of the G allele in AITD patients; Influence of CTLA-4 gene polymorphism on a common autoimmune process.
- Subjects
JAPAN; GENETIC polymorphisms; GENETICS of diabetes; AUTOIMMUNE thyroiditis
- Publication
Diabetes, 1998, Vol 47, Issue 1, p128
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.47.1.128