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- Title
Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction, and nerve blood flow in rats with streptozotocin-induced diabetes.
- Authors
Hotta, Nigishi; Koh, Naoki; Sakakibara, Fumihiko; Nakamura, Jiro; Hamada, Yoji; Hara, Tomohiro; Mori, Koichi; Nakashima, Eitaro; Naruse, Keiko; Fukasawa, Hideo; Kakuta, Hironobu; Sakamoto, Nobuo; Hotta, N; Koh, N; Sakakibara, F; Nakamura, J; Hamada, Y; Hara, T; Mori, K; Nakashima, E
- Abstract
The effect of a prostacyclin analog, beraprost sodium, on the electroretinogram, motor nerve conduction velocity, and nerve blood flow was determined in rats with streptozotocin-induced diabetes and was compared with the effect of insulin. Beraprost sodium (0.01 mg x kg-1 x day-1 for 8 weeks) significantly shortened the peak latency of the electroretinogram b-wave, increased tail nerve conduction velocity, and increased sciatic nerve blood flow in diabetic rats (P < 0.0003, 0.0001, and 0.0001 vs. untreated diabetic rats, respectively). This was accompanied by a significant increase in the 6-keto-prostaglandin F1alpha content of the thoracic aorta and a marked increase in the cAMP content of the sciatic nerve. Beraprost sodium had no effect on the sorbitol and fructose contents of the sciatic nerve and retina, but insulin (8-10 U/day) significantly reduced both parameters. These findings suggest that beraprost sodium may be useful for prevention of vascular and neural dysfunction in the retina and peripheral nerve.
- Publication
Diabetes, 1996, Vol 45, Issue 3, p361
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.45.3.361