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- Title
(REH08) Aerobic Reserve in People with Multiple Sclerosis: Measurement and Correlates.
- Authors
Feasel, Corey D.; Sandroff, Brian M.; Motl, Robert W.
- Abstract
Background: The concept of aerobic reserve reflects the available potential energy to perform essential tasks to maintain independent living and is calculated by subtracting the energetic demand for activities of daily living from peak aerobic power. To date, the concept of aerobic reserve has not been applied in multiple sclerosis (MS), and there are limited data on its measurement and correlates in this population. Objectives: This study described the measurement and correlates of aerobic reserve in MS. Methods: The sample included 23 people with MS who were fully ambulatory (median [range] Expanded Disability Status Scale [EDSS] score = 3.5 [2.0]). Participants completed a single session that included obtaining informed consent, EDSS examination, demographic questionnaire, as well as administration of the Symbol Digit Modalities Test (SDMT), Timed 25-Foot Walk Test (T25FW), 6-minute walk distance (6MWD), and a cardiopulmonary exercise test (CPET) performed on a treadmill (modified Balke protocol). Aerobic reserve was calculated by subtracting the person's steady-state VO2 extracted during the first stage of the CPET from peak VO2 obtained from the CPET. Results: Twenty-one of 23 participants met criteria for providing a maximal effort during the CPET. The mean (SD) aerobic reserve was 9.5 (± 3.7) mL/kg/min. Aerobic reserve strongly correlated with peak VO2 (mean [SD], 22.4 [±5.4] mL/kg/min), r = 0.77, P < .01. Aerobic reserve was positively correlated with SDMT raw score (mean [SD], 49.3 [±7.2]), r = 0.45, P = .03 and time to exhaustion in seconds on the CPET (mean [SD], 592.8 [±205.5]), r = 0.63, P < .01. Aerobic reserve was negatively correlated with resting heart rate (mean [SD], 79.4 [±11.5] bpm), r = -0.50, P = .02 and BMI (mean [SD], 29.6 [±5.8] kg/m²), r = -0.56, P < .01. Aerobic reserve did not correlate with age, sex, EDSS score, or T25FW or 6MWD results. Conclusions: Aerobic reserve can be measured during CPET in people with MS, and might have implications for understanding symptomatic and functional outcomes in people with MS.
- Subjects
AEROBIC exercises; CONFERENCES &; conventions; MULTIPLE sclerosis; AEROBIC capacity
- Publication
International Journal of MS Care, 2020, Vol 22, Issue S2, p70
- ISSN
1537-2073
- Publication type
Article