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- Title
Review: High-dose vitamin E supplementation is associated with increased all-cause mortality.
- Authors
Simon, Joel A.
- Abstract
This article focuses on a study related to high-dose vitamin E supplementation, which is associated with increased all-cause mortality. Randomized controlled trials that compared vitamin E supplementation with a control or placebo group in men or nonpregnant women, study duration and follow-up was 1 year and in this duration 10 deaths occurred. A dose-response analysis showed all-cause mortality increased as vitamin E dose increased 150 IU/d. The effect of vitamin E did not change after adjustment for differences in sex, mean age or mean follow-up. The association of high-dose vitamin E and mortality was stronger after adjustment for concomitant use of other vitamins and minerals.
- Subjects
VITAMIN E; MORTALITY; PLACEBOS; CLINICAL trials; SEX differences (Biology); MINERALS
- Publication
ACP Journal Club, 2005, Vol 143, Issue 1, p3
- ISSN
1056-8751
- Publication type
Article
- DOI
10.7326/acpjc-2005-143-1-001