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- Title
Novel IKZF1 rearrangement identified in a patient with blastic plasmacytoid dendritic cell neoplasm decreased haematopoietic stem cell function and promoted plasmacytoid dendritic cell abnormality.
- Authors
Yin, Le; Yu, Qian; Zhang, Huifang; Zhu, Hongkai; Deng, Zeyu; Xing, Cheng; Wang, Peilong; Zeng, Xiangju; Cheng, Zhao; Sheng, Yue; Peng, Hongling
- Abstract
This article discusses a study on a rare and aggressive blood cancer called blastic plasmacytoid dendritic cell neoplasm (BPDCN). The study focuses on a gene called IKZF1, which is important for blood cell development. The researchers identified a novel rearrangement of the IKZF1 gene in a BPDCN patient and investigated its effects on blood stem cells and plasmacytoid dendritic cells. They found that the rearrangement influenced the function and differentiation of these cells. The study provides insights into the underlying mechanisms of BPDCN and potential therapeutic targets. However, further research is needed to fully understand the role of IKZF1 in the disease.
- Subjects
HEMATOPOIETIC stem cells; CELL physiology; DENDRITIC cells; BONE marrow cells; POSITRON emission tomography computed tomography
- Publication
British Journal of Haematology, 2024, Vol 204, Issue 6, p2496
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19429