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- Title
Characteristics and outcomes of COVID‐19 in Chinese immune thrombocytopenia patients: A prospective cohort study.
- Authors
Chen, Yunfei; Liu, Jiaying; Shao, Shuai; Song, Zhen; Ma, Yueshen; Tuo, Yuanyuan; Fang, Lijun; Xu, Yanmei; Xu, Bingqi; Gu, Wenjing; Cao, Xuan; Chen, Jia; Yang, Yu; Wang, Panjing; Zhang, Jing; Xu, Yuan; Yu, Dandan; Hou, Pengxiao; Meng, Ke; Li, Zhirong
- Abstract
Summary: The coronavirus disease 2019 (COVID‐19) pandemic has a significant impact on the immune system. This is the first and largest study on pre‐existing immune thrombocytopenia (ITP) patients infected with COVID‐19 in China. We prospectively collected ITP patients infected with COVID‐19 enrolled in the National Longitudinal Cohort of Hematological Diseases (NICHE, NCT04645199) and followed up for at least 1 month after infection. One thousand and one hundred forty‐eight pre‐existing ITP patients were included. Two hundred and twelve (18.5%) patients showed a decrease in the platelet (PLT) count after infection. Forty‐seven (4.1%) patients were diagnosed with pneumonia. Risk factors for a decrease in the PLT count included baseline PLT count <50 × 109/L (OR, 1.76; 95% CI, 1.25–2.46; p = 0.001), maintenance therapy including thrombopoietin receptor agonists (TPO‐RAs) (OR, 2.27; 95% CI, 1.60–3.21; p < 0.001) and previous splenectomy (OR, 1.98; 95% CI, 1.09–3.61; p = 0.03). Risk factors for pneumonia included age ≥40 years (OR, 2.45; 95% CI, 1.12–5.33; p = 0.02), ≥2 comorbidities (OR, 3.47; 95% CI, 1.63–7.64; p = 0.001), maintenance therapy including TPO‐RAs (OR, 2.14; 95% CI, 1.17–3.91; p = 0.01) and immunosuppressants (OR, 3.05; 95% CI, 1.17–7.91; p = 0.02). In this cohort study, we described the characteristics of pre‐existing ITP patients infected with COVID‐19 and identified several factors associated with poor outcomes.
- Subjects
CHINA; IDIOPATHIC thrombocytopenic purpura; COVID-19; THROMBOPOIETIN receptor agonists; BLOOD diseases; COHORT analysis
- Publication
British Journal of Haematology, 2024, Vol 204, Issue 4, p1207
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19198