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- Title
Vascular "Long COVID": A New Vessel Disease?
- Authors
Zanini, Giada; Selleri, Valentina; Roncati, Luca; Coppi, Francesca; Nasi, Milena; Farinetti, Alberto; Manenti, Antonio; Pinti, Marcello; Mattioli, Anna Vittoria
- Abstract
Vascular sequelae following (SARS-CoV-2 coronavirus disease) (COVID)-19 infection are considered as "Long Covid (LC)" disease, when occurring 12 weeks after the original infection. The paucity of specific data can be obviated by translating pathophysiological elements from the original Severe Acute Respiratory Syndrome-Corona Virus (SARS-CoV-2) infection (In a microcirculatory system, a first "endotheliitis," is often followed by production of "Neutrophil Extracellular Trap," and can evolve into a more complex leukocytoklastic-like and hyperimmune vasculitis. In medium/large-sized vessels, this corresponds to endothelial dysfunction, leading to an accelerated progression of pre-existing atherosclerotic plaques through an increased deposition of platelets, circulating inflammatory cells and proteins. Associated dysregulated immune and pro-coagulant conditions can directly cause thrombo-embolic arterial or venous complications. In order to implement appropriate treatment, physicians need to consider vascular pathologies observed after SARS-Cov-2 infections as possible "LC" disease.
- Subjects
VASCULAR disease diagnosis; COVID-19; ENDOTHELIUM; BLOOD proteins; POST-acute COVID-19 syndrome; BLOOD platelets; MICROCIRCULATION; NEUTROPHILS; THROMBOEMBOLISM; VASCULAR diseases; EXTRACELLULAR space; VASCULITIS
- Publication
Angiology, 2024, Vol 75, Issue 1, p8
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/00033197231153204