We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Placebo effects in children with autism spectrum disorder.
- Authors
Curie, Aurore; Oberlander, Tim F.; Jensen, Karin B.
- Abstract
Placebo responses are frequently observed in research studies and clinical contexts, yet there is limited knowledge about the placebo effect among children with neurodevelopmental disorders. Here, we review the placebo effect in autism spectrum disorder (ASD). Placebo responses are widely evident in ASD clinical trials and could partly operate via so‐called placebo‐by‐proxy, whereby caregivers or clinicians indirectly shape patient outcomes. Understanding the role of placebo effects in ASD may help discern genuine treatment effects from contextual factors in clinical trials. The much less studied nocebo effect, or negative placebo, might contribute to the experience of side effects in ASD treatments but empirical data is missing. Better knowledge about placebo and nocebo mechanisms may contribute to the development of more effective research designs, such as three‐armed designs that account for natural history, and improved treatments for ASD symptoms. At a clinical level, deeper knowledge about placebo and nocebo effects may optimize the delivery of care for individuals with ASD in the future. What this paper adds: Placebo responses are evident in autism spectrum disorder (ASD) clinical trials.Placebo responses in ASD are likely dependent on a placebo‐by‐proxy mechanism. What this paper adds: Placebo responses are evident in autism spectrum disorder (ASD) clinical trials.Placebo responses in ASD are likely dependent on a placebo‐by‐proxy mechanism.
- Subjects
CHILDREN with autism spectrum disorders; PLACEBOS; AUTISM spectrum disorders; NOCEBOS
- Publication
Developmental Medicine & Child Neurology, 2023, Vol 65, Issue 10, p1316
- ISSN
0012-1622
- Publication type
Article
- DOI
10.1111/dmcn.15574