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- Title
The analgesic effect of metformin on paclitaxel-induced neuropathic pain model in rats: By considering pathological results.
- Authors
Hacimuftuoglu, Ahmet; Mohammadzadeh, Maryam; Taghizadehghalehjoughi, Ali; Taspinar, Numan; Togar, Basak; Nalcı, Kemal; Okkay, Ufuk; Gundogdu, Betul; Nalcı, Kemal Alp
- Abstract
<bold>Background and Objective: </bold>Metformin (MET) has been used as an antidiabetic agent for type II diabetes. At the same time, recent researches have shown that the clinical improvement of MET is useful for nerve damage. In this study, we investigated the analgesic effect of MET in paclitaxel (PAC)-induced neuropathic pain.<bold>Materials and Methods: </bold>Forty-two adult, female rats, Wistar strain weighing 220 ± 10 g were randomly divided into 5 experimental groups. PAC was intraperitoneally (IP) administered (2.0 mg/kg) for 4 groups every other day (0, 2, 4, and 6 days). By the 30th day, MET (100, 200, and 400 mg/kg) was administered to 4 groups. Before and after treatment, basal pain threshold values were measured with Randall-Selitto analgesiometer test. At the end of experiment, pathological values were measured in selected regions including brain (motor cortex, M1), spinal cord (L4-L5), sciatic nerve, and muscle.<bold>Results: </bold>According to our results, PAC-induced neuropathic pain reached to highest level at 14th day. Four hundred milligram/kilogram concentration of MET remarkably decreased PAC-induced neuropathic pain. On the other hand, pathologic features have shown that PAC had significant pathological change in the brain and spinal cord while in the peripheral nerves and muscles had not shown any pathological change.<bold>Conclusion: </bold>The pathological results of the current study for the first time demonstrated that MET beside of its antidiabetic effects reversed neuropathic pain induced by PAC. Consequently, this research can be promising for cancer patients that suffering from neuropathic pain induced by anticancer drugs.
- Subjects
TYPE 2 diabetes; PERIPHERAL nervous system; PAIN threshold; SCIATIC nerve; MOTOR cortex; BIOLOGICAL models; ANALGESICS; NEURALGIA; HYPOGLYCEMIC agents; ANTINEOPLASTIC agents; RATS; TUMORS; PACLITAXEL; METFORMIN; ANIMALS; PHARMACODYNAMICS; DISEASE complications
- Publication
Journal of Cancer Research & Therapeutics, 2020, Vol 16, Issue 1, p34
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/jcrt.JCRT_1455_16