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- Title
18F-FDG PET/CT in bone sarcoidosis: an observational study.
- Authors
Demaria, Lucie; Borie, Raphael; Benali, Khadija; Piekarski, Eve; Goossens, Julia; Palazzo, Elisabeth; Forien, Marine; Dieudé, Philippe; Crestani, Bruno; Ottaviani, Sébastien
- Abstract
Objective: Bone sarcoidosis is usually rare. Imaging procedures such as fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) can reveal bone sarcoidosis with better sensitivity than conventional radiography. We aimed to describe bone sarcoidosis involvement detected with 18F-FDG PET/CT. Methods: This was an observational retrospective study of individuals with pulmonary sarcoidosis who underwent 18F-FDG PET/CT. According to the ATS/ERS/WASOG criteria, sarcoidosis was diagnosed by the presence of clinical and/or imaging features of sarcoidosis and evidence of non-caseating epithelioid granulomas on a biopsy. We assessed clinical and 18F-FDG PET/CT characteristics. Results: Data for 85 patients with sarcoidosis (56.5% female, median age 47 [range 21–80] years) were analyzed. The median follow-up was 4 years. Among 56 patients, sarcoidosis occurred in more than three organs. According to ATS/ERS/WASOG criteria, bone sarcoidosis was diagnosed in 12 (14%) patients. The spine was the most commonly affected location (92%, n = 11), followed by the pelvis (67%, n = 8), sternum (33%, n = 4), humerus (25%, n = 3), and fingers (17%, n = 2). Only peripheral adenopathy was associated with bone sarcoidosis (p = 0.04). Seven patients had a 18F-FDG PET/CT follow-up, all showing a decrease of bone lesions. Conclusion: Bone sarcoidosis occurred in 14% of patients with sarcoidosis, affecting multiple bones and mostly the axial skeleton. 18F-FDG PET/CT seems a sensitive tool for diagnosis and follow-up of bone sarcoidosis. Key Points • Bone sarcoidosis is not rare. • Bone sarcoidosis affects mainly the axial skeleton. • 18F-FDG PET/CT is useful for diagnosis and follow-up of bone sarcoidosis.
- Subjects
SARCOIDOSIS; BONES; FLUORODEOXYGLUCOSE F18; POSITRON emission tomography computed tomography; SCIENTIFIC observation; STERNUM; COMPUTED tomography
- Publication
Clinical Rheumatology, 2020, Vol 39, Issue 9, p2727
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-020-05022-6