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- Title
Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis.
- Authors
Kalmanson, Olivia A.; McLoughlin, Kaitlin C.; Kiser, Tyree H.; Gubbels, Samuel P.
- Abstract
Introduction: Aminoglycoside antibiotics such as gentamicin are bactericidal and effective against gram negative organisms and act synergistically against gram positive organisms, including S taphylococcus aureus. However, they have serious adverse effects such as nephrotoxicity and ototoxicity. Gentamicin ototoxicity may occur after a single dose and results in decreased vestibular function, which is frequently debilitating and often permanent. Objective: To emphasize the risk of gentamicin ototoxicity and suggest alternative antibiotics in penicillin-allergic patients undergoing surgery. Case Summary: We present a case of a woman with preexisting Meniere's Disease who received gentamicin 400 mg perioperatively for a sigmoidectomy due to a penicillin allergy listed in the patient's medical record. The patient developed severe ototoxicity preventing her from working or driving. Physical examination was remarkable for a broad-based gait requiring assistance to walk and bilateral corrective saccades. Vestibular testing revealed high-grade bilateral vestibular loss associated with all semicircular canals, a considerable decline compared to her function 3 years prior. Discussion: Gentamicin is indicated for surgical prophylaxis when a patient has a true allergy to penicillins and cannot receive cephalosporins, though alternatives exist. True allergies include IgE-mediated illness (anaphylaxis, bronchospasm, or urticaria 30-60 minutes after administration) or exfoliative reactions (Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis). The authors encourage more prudent use of gentamicin, especially in patients susceptible for debilitating otologic insults, and offer recommendations for alternative agents prior to using gentamicin.
- Subjects
COLON surgery; RECTAL surgery; ELECTIVE surgery; PHYSICAL diagnosis; NEUROLOGICAL disorders; SACCADIC eye movements; GENTAMICIN; SURGERY; PATIENTS; SENSORINEURAL hearing loss; PENICILLIN; MEDICAL protocols; ANTIBIOTIC prophylaxis; GAIT disorders; VESTIBULAR function tests; OTOTOXICITY; MENIERE'S disease; AUDIOMETRY; DRUG allergy; DIVERTICULITIS; DISEASE risk factors
- Publication
Annals of Otology, Rhinology & Laryngology, 2023, Vol 132, Issue 12, p1686
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/00034894231176333