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- Title
The pharmacological protection of renal function in patients undergoing cardiac surgery.
- Authors
Narin, Emine Bilge; Oztekin, Ilhan; Oztekin, SeherDeniz; Ogutmen, Betul
- Abstract
Objectives: To compare the effects of different routes and timings of administration of dopamine and mannitol used to alleviate the adverse effects of prolonged cardiopulmonary bypass (CPB) on renal functions in coronary artery surgery. Methods: Group I (n: 25 patients): Mannitol 1 g/kg was added into the priming solution for CPB. Group II (n: 25 patients): IV dopamine was administered at a dose of 2 µg/kg/min during the time period between anesthesia induction and end of surgery. Group III (n: 25 patients): IV dopamine was administered at a dose of 2 µg/kg/min during the time period between anesthesia induction and end of surgery and mannitol 1 g/kg was added into the priming solution for CPB. Group IV (n: 25 patients) (Controls): Furosemide was given when the urine output was low. Results: There was a significant increase in post operative urine microalbumin/creatinine ratio in all groups (p < 0.05), even increase of cystatin-c in Groups I, II and III (p < 0.01). Conclusions: We believe that concurrent use of dopamine infusion (2 µg/kg/min) with mannitol (1 g/kg) during CPB may represent a more effective strategy for the prevention of the untoward effects of CPB on renal functions.
- Subjects
PHARMACOLOGY; RENAL artery diseases; CARDIAC surgery; DOPAMINE; MANNITOL; DRUG side effects; ANESTHESIA
- Publication
Pakistan Journal of Medical Sciences, 2015, Vol 31, Issue 5, p1
- ISSN
1682-024X
- Publication type
Article
- DOI
10.12669/pjms.315.7679