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- Title
Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery.
- Authors
Ravikumar, Sambandam; Baylon, Mary Grace; Park, Si Jae; Jong-il Choi
- Abstract
Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
- Subjects
BIOSENSORS; NANOBIOTECHNOLOGY; MEDICAL equipment; BIOREMEDIATION; WASTE management biodegradation
- Publication
Microbial Cell Factories, 2017, Vol 16, p1
- ISSN
1475-2859
- Publication type
Article
- DOI
10.1186/s12934-017-0675-z