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- Title
Cord blood transplantation is associated with good outcomes in secondary Acute Myeloid Leukaemia in first remission.
- Authors
Baron, F.; Labopin, M.; Ruggeri, A.; Volt, F.; Mohty, M.; Blaise, D.; Chevallier, P.; Sanz, J.; Fegueux, N.; Cornelissen, J. J.; Rambaldi, A.; Savani, B. N.; Gluckman, E.; Nagler, A.
- Abstract
<bold>Background: </bold>We conducted a retrospective survey within the European Society for Blood and Marrow Transplantation (EBMT) registry to assess the outcomes of cord blood transplantation (CBT) in secondary acute myeloid leukaemia (sAML).<bold>Methods: </bold>Inclusion criteria consisted of ≥18 years of age, sAML, first CBT between 2002 and 2016, and either first complete remission (CR) or active disease at CBT.<bold>Results: </bold>One hundred forty-six patients met the study inclusion criteria. Status at transplantation was first CR (n = 97), primary refractory sAML (n = 30) or relapsed (n = 19) sAML. Neutrophil engraftment was achieved in 118 patients while the remaining 25 patients (17%) failed to engraft. This includes 13% of patients transplanted in first CR versus 30% of those transplanted with active disease (P = 0.008). Two-year incidences of relapse were 25% in first CR patients versus 36% in those with advanced disease (P = 0.06) while 2-year incidences of nonrelapse mortality were 35% and 49% (P = 0.03), respectively. At 2-year overall survival, leukaemia-free survival and graft-versus-host disease (GVHD)-free relapse-free survival were 42% vs. 19% (P < 0.001), 40% vs. 16% (P < 0.001), and 26% vs. 12% (P = 0.002) in first CR patients versus those with advanced disease, respectively.<bold>Conclusions: </bold>We report here the first study of CBT in a large cohort of sAML patients. Main observation was that CBT rescued approximately 40% of patients with sAML in first CR.
- Subjects
CORD blood transplantation; GRAFT versus host disease; ACUTE myeloid leukemia treatment; HEMATOPOIETIC stem cell transplantation; PROGNOSIS; DISEASE relapse; TREATMENT effectiveness; DISEASE remission
- Publication
Journal of Internal Medicine, 2019, Vol 285, Issue 4, p446
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1111/joim.12870