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- Title
Characterization of γδ T cell subsets in organ transplantation.
- Authors
Puig-Pey, Isabel; Bohne, Felix; Benítez, Carlos; López, Marta; Martínez-Llordella, Marc; Oppenheimer, Federico; Lozano, Juan José; González-Abraldes, Juan; Tisone, Giuseppe; Rimola, Antoni; Sánchez-Fueyo, Alberto
- Abstract
γδ T cells are innate-type lymphocytes that preferentially act as regulators of local effector immune responses. Recent reports found an altered distribution of the two main subpopulations of blood γδ T cells (Vδ1 and Vδ2) in operationally tolerant liver transplant recipients. Based on this, γδ T cells subset quantification was proposed as a biomarker of immunologic risk in liver transplantation. The specific characteristics of γδ T cell subsets in transplantation remain however unknown. We have investigated here the phenotype, repertoire and functional properties of γδ T cell subsets in a large population of allograft recipients. Our results indicate that alterations in the γδ T cell compartment are not restricted to tolerant liver recipients. In fact, most immunosuppressed liver and kidney recipients also display an enlarged peripheral blood γδ T cell pool mainly resulting from an expansion of Vδ1 T cells exhibiting an oligoclonal repertoire and different phenotypic and cytokine production traits than Vδ2 T cells. We propose that persistent viral infections are likely to contribute to these alterations. Our data provide novel insight in the biology of γδ T cells and a rationale for exploring these lymphocytes in more depth into the pathogenesis of viral infections in transplantation.
- Subjects
LYMPHOCYTES; LIVER transplantation; T cells; IMMUNE response; VIRUS diseases
- Publication
Transplant International, 2010, Vol 23, Issue 10, p1045
- ISSN
0934-0874
- Publication type
Article
- DOI
10.1111/j.1432-2277.2010.01095.x