We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Native T<sub>1</sub> mapping for characterization of acute and chronic myocardial infarction in swine: Comparison with contrast-enhanced MRI.
- Authors
Liu, Xi; Hou, Jiang‐long; Yang, Zhi‐gang; Xia, Chun‐chao; Xie, Lin‐jun; Ye, Peng‐fei; Peng, Wan‐lin; Li, Lei; Yang, Meng‐xi; Guo, Ying‐kun; Hou, Jiang-Long; Yang, Zhi-Gang; Xia, Chun-Chao; Xie, Lin-Jun; Ye, Peng-Fei; Peng, Wan-Lin; Yang, Meng-Xi; Guo, Ying-Kun
- Abstract
<bold>Background: </bold>Both acute and chronic myocardial infarction (AMI and CMI, respectively) exhibit delayed enhancement; however, clinical decision-making processes frequently require the differentiation of these two types of myocardial injury.<bold>Purpose: </bold>To investigate the reliability of AMI and CMI characterization using native T1 mapping and its feasibility for discriminating AMI from CMI.<bold>Study Type: </bold>Case-control.<bold>Animal Model: </bold>The study cohort comprised 12 AMI (mean post-MI, 3.75 ± 1.29 days) and 15 CMI (mean post-MI, 39.53 ± 6.10 days) Bama mini-pigs.<bold>Field Strength/sequence: </bold>Balanced steady-state free precession (bSSFP), segmented-turbo-FLASH-PSIR, and modified Look-Locker inversion recovery (MOLLI) sequences at 3.0T.<bold>Assessment: </bold>The infarct sizes were compared on matching short-axis slices of late-gadolinium-enhanced (LGE) images and T1 maps by two experienced radiologists.<bold>Statistical Tests: </bold>The infarct sizes were compared on matching short-axis slices of LGE images and T1 maps, and agreement was determined using linear regression and Bland-Altman analyses. The native T1 values were compared between AMI and CMI models (independent sample t-test). The intraclass correlation coefficient was used to assess inter- and intraobserver variability.<bold>Results: </bold>Measured infarct sizes did not differ between native T1 mapping and LGE images (AMI: P = 0.913; CMI: P = 0.233), and good agreement was observed between the two techniques (AMI: bias, -3.38 ± 19.38%; R2 = 0.96; CMI: bias, -10.55 ± 10.90%; R2 = 0.90). However, the native infarction myocardium T1 values and the T1 signal intensity ratio of infarct and remote myocardium (T1 SI ratio) did not differ significantly between AMI and CMI (P = 0.173).<bold>Data Conclusion: </bold>Noncontrast native T1 mapping can accurately determine acute and chronic infarct areas as well as conventional LGE imaging; however, it cannot distinguish acute from chronic MI.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1406-1414.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 47, Issue 5, p1406
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25871