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- Title
Early marker of regional left ventricular deformation in patients with hypertrophic cardiomyopathy evaluated by MRI tissue tracking: The effects of myocardial hypertrophy and fibrosis.
- Authors
Xu, Hua‐yan; Chen, Jing; Yang, Zhi‐gang; Li, Rui; Shi, Ke; Zhang, Qin; Liu, Xi; Xie, Lin‐jun; Jiang, Li; Guo, Ying‐kun; Xu, Hua-Yan; Yang, Zhi-Gang; Xie, Lin-Jun; Guo, Ying-Kun
- Abstract
<bold>Purpose: </bold>To evaluate the regional left ventricular (LV) myocardial strain of early stage hypertrophic cardiomyopathy (HCM) patients by magnetic resonance (MR) tissue tracking.<bold>Materials and Methods: </bold>In all, 114 adult HCM patients classified as NYHA I or II and 32 healthy volunteers were enrolled and underwent 3.0T MR examination. Vertical 2-chamber long axis, horizontal 4-chamber, and short axis cine sequence as well as late gadolinium enhancement images (LGE) were scanned. The cardiac function, regional LV tissue tracking variables, end-diastolic wall thickness (EDTH), and LGE extent were measured.<bold>Results: </bold>In the HCM group, 38 were NYHA I and 76 were NYHA II. By regional analysis, peak strain (PS) and peak displacement (PD) with radial, circumferential direction of hypertrophic segments (n = 283) were significantly lower than nonhypertrophic segments (n = 1541) (all P < 0.05). Radial PS was significantly correlated with LVEDTH (r = -0.467, P < 0.0001). Radial PD was negatively associated with LVEDTH (r = -0.331, P < 0.0001). The PS and PD of all directions were decreased in segments with LGE (n = 723) compared with those without LGE (n = 1101) (all P < 0.05). In addition, radial PS and PD were negatively associated with LGE extent (radial PS, r = -0.441; radial PD, r = -0.274; both P < 0.0001). All strain parameters showed excellent inter- and intraobserver agreements.<bold>Conclusion: </bold>Decreased regional LV myocardial strain hypertrophic and fibrotic segments of early-stage HCM patients can be measured by MR tissue tracking based on routine cine images. Moreover, myocardial strain may decrease with the increasing of myocardial hypertrophy as well as fibrosis.<bold>Level Of Evidence: </bold>2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1368-1376.
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 46, Issue 5, p1368
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25681