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- Title
α‐Thianthrenium Carbonyl Species: The Equivalent of an α‐Carbonyl Carbocation.
- Authors
Jia, Hao; Ritter, Tobias
- Abstract
Here we report an α‐thianthrenium carbonyl species, as the equivalent of an α‐carbonyl carbocation, which is generated by the radical conjugate addition of a trifluoromethyl thianthrenium salt to Michael acceptors. The reactivity allows for the synthesis of Cα‐tetrasubstituted α‐ and β‐amino acid analogues via a Ritter reaction by addition of acetonitrile. Addition of hydroxide, methoxide, and even fluoride can afford α‐heteroatom substituted α‐phenylpropanoates.
- Subjects
CARBOCATIONS; ADDITION reactions; SPECIES; ACETONITRILE
- Publication
Angewandte Chemie, 2022, Vol 134, Issue 39, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202208978