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- Title
Rhodium‐Catalyzed [4+2+1] Cycloaddition of In Situ Generated Ene/Yne‐Ene‐Allenes and CO.
- Authors
Tian, Zi‐You; Cui, Qi; Liu, Cheng‐Hang; Yu, Zhi‐Xiang
- Abstract
Reported herein is the first rhodium‐catalyzed [4+2+1] cycloaddition of in situ generated ene/yne‐ene‐allenes and CO to synthesize challenging seven‐membered carbocycles fused with five‐membered rings. This reaction is designed based on the 1,3‐acyloxy migration of ene/yne‐ene‐propargyl esters to ene/yne‐ene‐allenes, followed by oxidative cyclization, CO insertion, and reductive elimination to form the final [4+2+1] cycloadducts. The possible competing [4+1], [4+2], and [2+2+1] cycloadditions were disfavored, making the present reaction an efficient way to access functionalized 5/7 rings.
- Subjects
RHODIUM; RING formation (Chemistry); ENE reactions; ALKENES; ESTERS
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 47, p15770
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201805908