We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Redox‐Divergent Synthesis of Fluoroalkylated Pyridines and 2‐Pyridones through Cu‐Catalyzed N−O Cleavage of Oxime Acetates.
- Authors
Bai, Dachang; Wang, Xueli; Zheng, Guangfan; Li, Xingwei
- Abstract
Abstract: Cu‐catalyzed redox‐divergent [3+3] coupling of oxime esters with β‐CF3 enones and acrylates is described. This redox‐neutral coupling with enones and acrylates affords trifluoromethylated pyridines and pyridones, respectively. Under reductive conditions, difluoromethylated pyridines, difluoromethlated pyridones, and trifluoromethylated dihydropyridones are obtained. The reactions occur under mild conditions with broad substrate scope and regio/redox selectivity.
- Subjects
ALKYLATION; OXIDATION-reduction reaction; PYRIDINE synthesis; PYRIDONE; COPPER catalysts; ACETATES
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 22, p6743
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201802311