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- Title
Palladium-Catalyzed Asymmetric Synthesis of Silicon-Stereogenic 5,10-Dihydrophenazasilines via Enantioselective 1,5-Palladium Migration.
- Authors
Sato, Yosuke; Takagi, Chihiro; Shintani, Ryo; Nozaki, Kyoko
- Abstract
A palladium-catalyzed asymmetric synthesis of silicon-stereogenic 5,10-dihydrophenazasilines was developed that proceeds via an unprecedented enantioselective 1,5-palladium migration. High enantioselectivity was achieved by employing 4,4′-bis(trimethylsilyl) ( R)-Binap as the chiral ligand, and a series of mechanistic investigations were carried out to probe the catalytic cycle of this process.
- Subjects
SILICON compounds; CHEMICAL synthesis; PALLADIUM; ENANTIOSELECTIVE catalysis; MIGRATION reactions (Chemistry)
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 31, p9339
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201705500