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- Title
Clinical outcome and T2 assessment following autologous matrix-induced chondrogenesis in osteochondral lesions of the talus.
- Authors
Kubosch, Eva; Erdle, Benjamin; Izadpanah, Kaywan; Kubosch, David; Uhl, Markus; Südkamp, Norbert; Niemeyer, Philipp; Kubosch, Eva Johanna; Südkamp, Norbert P
- Abstract
<bold>Purpose: </bold>Scientific evidence for the treatment of osteochondral lesions (OCLs) of the talus is limited. The aim of this study was an evaluation of the clinical outcome after a one-step autologous subchondral cancellous bone graft and autologous matrix-induced chondrogenesis (AMIC) in medial OCLs of the talus and the assessment of the repair tissue (RT).<bold>Methods: </bold>Seventeen patients (eight women, nine men; mean age, 38.8 ± 15.7 years) with an OCL of the medial talus underwent surgery. Clinical and radiological assessment was performed after a mean follow-up of 39.5 ± 18.4 months, including established scoring systems (American Orthopaedic Foot and Ankle Society [AOFAS] Score, Foot Function Index [FFI], visual analogue scale [VAS]), evaluation of Magnetic Resonance Observation of Cartilage Repair Tissue scoring system (MOCART Score) and T2 mapping.<bold>Results: </bold>Preoperative pain (7.8 ± 2.1) significantly improved to an average of 3.2 ± 2.4 postoperatively. AOFAS Score averaged 82.6 ± 13.4, MOCART Score 52.7 ± 15.9. Mean T2 relaxation time of the RT was 41.6 ± 6.3 ms and showed no significant differences to the surrounding cartilage (mean, 38.8 ± 8.5; p = 0.58). MOCART Score significantly correlated with the AOFAS Score (rho = 0.574, p = 0.040). T2 relaxation time of the RT significantly correlated with the MOCART Score (rho = 0.593, p = 0.033).<bold>Conclusions: </bold>The one-step autologous subchondral cancellous bone grafting and AMIC leads to a significant reduction in postoperative pain and satisfying postoperative functional outcome in mid-term follow-up. Magnetic resonance imaging (MRI) assessment demonstrated a good quality of regenerative tissue similar to the MRI ultrastructure of the surrounding cartilage.
- Subjects
CHONDROGENESIS; ANKLEBONE; OSTEOCHONDRITIS; CANCELLOUS bone; BONE grafting; HEALTH outcome assessment; DISEASES; CARTILAGE; ANKLEBONE surgery; AUTOGRAFTS; LONGITUDINAL method; MAGNETIC resonance imaging; POSTOPERATIVE pain; WOUND healing; VISUAL analog scale; TREATMENT effectiveness; SURGERY
- Publication
International Orthopaedics, 2016, Vol 40, Issue 1, p65
- ISSN
0341-2695
- Publication type
journal article
- DOI
10.1007/s00264-015-2988-z