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- Title
Electron Orbital Hybridization‐Enhanced Copper‐Nanocatalysis for Anti‐Infection.
- Authors
Luo, Yao; Ruan, Zesong; Guo, Zhao; Chen, Yunfeng; Lin, Han; Ge, Min; Zhu, Chen
- Abstract
Recurrent bacterial infections, impenetrable microbial biofilms, and irremediable antibiotic resistance are the most perilous threats in orthopedic implant‐associated infections (IAIs). Recently, chemodynamic therapy (CDT) has been considered a promising therapy, while the clinical practices for existing CDT agents are limited by the low therapeutic efficiency in physiological circumstances. Herein, it is demonstrated that silica‐copper nanosheets (Si@Cu NSs) exhibit a combined therapeutic photothermal‐chemodynamic strategy for IAIs treatment with superior capacity and biocompatibility. This unique design endows the nanostructure with enhanced copper‐based Fenton‐like properties via p‐d orbital hybridization by incorporating copper nanoclusters (Cu NCs) on silicene nanosheets (Si NSs) matrix, integrating inherent photothermal performance of Si NSs with specific catalytic anti‐infection of Cu NCs against planktonic bacteria and biofilms both in vitro and in vivo. This study not only reveals the promising bio‐application prospects of 2D nanocatalytic biomaterials but also demonstrates the feasibility of constructing novel CDT agents by orbital hybridization for the catalytic treatment of IAIs.
- Subjects
ORBITAL hybridization; COPPER; DRUG resistance in bacteria; BACTERIAL diseases; ELECTRONS; MICROBIAL fuel cells
- Publication
Advanced Functional Materials, 2024, Vol 34, Issue 22, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202313742