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- Title
Twelve New Seco-Pregnane Glycosides from Cynanchum taihangense.
- Authors
Wang, Yu-Bo; Zhao, Dan; Su, Shan-Shan; Chen, Gang; Wang, Hai-Feng; Pei, Yue-Hu
- Abstract
For our interest in the potential biologically active and structurally unique steroidal glycosides, continued phytochemical investigation of Cynanchum taihangense was carried out; twelve new seco-pregnane glycosides, cynataihosides I–L (1–4), M-T (7–14), and two known glycosides, glaucoside A (5) and atratcynoside F (6), were isolated from the 95% ethanol extract of Cynanchum taihangense. Two new aglycones were found among compounds 10, 11, 13, and 14. The structures of the glycosides were elucidated based on 1D and 2D NMR spectroscopic data, HR-ESI-MS analysis, and chemical evidence. The cytotoxicity of compounds against three human tumor cell lines (HL-60, THP-1, and PC-3) were evaluated by MTT assay. Compound 11 displayed significant cytotoxicity against THP-1 and PC-3 cell line with IC50 values of 5.08 and 22.75 μm, respectively. Compounds 3 and 14 exhibited moderate and selective cytotoxicity on HL-60 and THP-1 with IC50 values of 17.78 and 16.02 μm, respectively.
- Subjects
GLYCOSIDES; CELL lines; AGLYCONES
- Publication
Molecules, 2022, Vol 27, Issue 17, p5500
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27175500