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- Title
Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines.
- Authors
Fernández-Acosta, Roberto; Iriarte-Mesa, Claudia; Alvarez-Alminaque, Daniel; Hassannia, Behrouz; Wiernicki, Bartosz; Díaz-García, Alicia M.; Vandenabeele, Peter; Vanden Berghe, Tom; Pardo Andreu, Gilberto L.
- Abstract
The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation.
- Subjects
IRON oxide nanoparticles; CANCER cells; CELL lines; IRON oxides; IRON chelates; GALLIC acid; POLYACRYLIC acid
- Publication
Molecules, 2022, Vol 27, Issue 13, p3970
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27133970