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- Title
Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study.
- Authors
Shady, Nourhan Hisham; Hayallah, Alaa M.; Mohamed, Mamdouh F. A.; Ghoneim, Mohammed M.; Chilingaryan, Garri; Al-Sanea, Mohammad M.; Fouad, Mostafa A.; Kamel, Mohamed Salah; Abdelmohsen, Usama Ramadan
- Abstract
Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this study, we investigated 14 natural compounds isolated from Amphimedon sp. via a molecular docking study, to examine their ability to act as anti-COVID-19 agents. Moreover, the pharmacokinetic properties of the most promising compounds were studied. The docking study showed that virtually screened compounds were effective against the new coronavirus via dual inhibition of SARS-CoV-2 RdRp and the 3CL main protease. In particular, nakinadine B (1), 20-hepacosenoic acid (11) and amphimedoside C (12) were the most promising compounds, as they demonstrated good interactions with the pockets of both enzymes. Based on the analysis of the molecular docking results, compounds 1 and 12 were selected for molecular dynamics simulation studies. Our results showed Amphimedon sp. to be a rich source for anti-COVID-19 metabolites.
- Subjects
COVID-19; SARS-CoV-2; MOLECULAR dynamics; MOLECULAR docking; PANDEMICS
- Publication
Molecules, 2021, Vol 26, Issue 12, p3775
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26123775