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- Title
Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill.
- Authors
Giorno, Thais Biondino Sardella; Santos, Carlos Henrique Corrêa dos; Carvalho, Mario Geraldo de; Silva, Virgínia Cláudia da; Sousa, Paulo Teixeira de; Fernandes, Patricia Dias; Boylan, Fabio; Capasso, Raffaele; Mannelli, Lorenzo Di Cesare
- Abstract
Infusions of roots of Siolmatra brasiliensis (Cogn.) Baill, ("taiuiá", "cipó-tauá") are used for toothache pain and ulcers. We aimed to study the antinociceptive effects and identify the possible mechanism of action of this plant and its isolated substances (cayaponoside A1, cayaponoside B4, cayaponoside D, and siolmatroside I). Hydroethanol extract (HE), ethyl acetate fraction (EtOAc), and isolated saponins were evaluated in chemical and thermal models of pain in mice. Animals were orally pretreated and evaluated in the capsaicin- or glutamate-induced licking and in the hot plate tests. The antinociceptive mechanism of action was evaluated using the hot plate test with the following pretreatments: Atropine (cholinergic antagonist), naloxone (opioid antagonist), or L-NAME (nitric oxide synthase inhibitor). All extracts and isolated saponins increased the area under the curve in the hot plate test. Tested substances induced a higher effect than the morphine-treated group. Our data suggest that stems of S. brasiliensis and their isolated substances present antinociceptive effects. Cholinergic and opioidergic pathways seem to be involved in their mechanism of action. Taken together our data corroborate the traditional use of the plant and expands the information regarding its use.
- Subjects
SAPONINS; BIOCHEMICAL mechanism of action; NITRIC-oxide synthases; SENSITIVE plant; CHEMICAL models; ETHYL acetate
- Publication
Molecules, 2019, Vol 24, Issue 24, p4584
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24244584