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- Title
Chemical Composition and Biological Activities of Metabolites from the Marine Fungi Penicillium sp. Isolated from Sediments of Co To Island, Vietnam.
- Authors
Le, Hong Minh Thi; Do, Quynh Thi; Doan, Mai Huong Thi; Vu, Quyen Thi; Nguyen, Mai Anh; Vu, Thu Huyen Thi; Nguyen, Hai Dang; Duong, Nguyen Thi Thuy; Tran, Manh Hung; Chau, Van Minh; Pham, Van Cuong; McPhee, Derek J.
- Abstract
Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment Penicillium species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (1), 3-indolecarbaldehyde (2), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3), 2-[(2R-hydroxypropanoyl)amino]benzamide (4), 4-hydroxybenzandehyde (5), chrysogine (6), 3-acetyl-4-hydroxycinnoline (7), acid 1H-indole-3-acetic (8), cyclo (Tyr-Trp) (9), and 2',3'-dihydrosorbicillin (10). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3) showed a strong inhibitory effect against Enterococcus faecalis with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2R-hydroxypropanoyl)amino]benzamide (4) and 4-hydroxybenzandehyde (5) selectively inhibited E. coli with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2',3'-Dihydrosorbicillin (10) potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%).
- Subjects
VIETNAM; MARINE fungi; PENICILLIUM; MARINE microorganisms; MARINE sediments; METABOLITES; ENTEROCOCCUS faecalis; OCHRATOXINS; MICROBIAL metabolites
- Publication
Molecules, 2019, Vol 24, Issue 21, p3830
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24213830