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- Title
Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells.
- Authors
Kim, Hyo-Young; Han, Ah-Reum; Kil, Yun-Seo; Seo, Eun Kyoung; Jin, Chang Hyun
- Abstract
Catalpa ovata (Bignoniaceae) is widely distributed throughout Korea, China, and Japan. This study investigated the anti-inflammatory effects of catalpalactone isolated from C. ovata in lipopolysaccharide (LPS)-induced RAW264.7 cells. Catalpalactone significantly inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in LPS-induced RAW264.7 cells. The levels of cytokines such as interleukin-6 and tumor necrosis factor-α were reduced under catalpalactone exposure in LPS-induced RAW264.7 cells. Additionally, catalpalactone suppressed signal transducer and activator of transcription 1 (STAT-1) protein expression and interferon-β (IFN-β) production. Treatment with catalpalactone prevented interferon regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) activation. Taken together, these results suggest that the anti-inflammatory effects of catalpalactone are associated with the suppression of NO production and iNOS expression through the inhibition of IRF3, NF-κB, and IFN-β/STAT-1 activation.
- Subjects
LIPOPOLYSACCHARIDES; TUMOR necrosis factors; ANTI-inflammatory agents; NITRIC-oxide synthases; NITRIC oxide
- Publication
Molecules, 2019, Vol 24, Issue 7, p1236
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24071236