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- Title
One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents.
- Authors
Gomha, Sobhi M.; Kheder, Nabila A.; Abdelhamid, Abdou O.; Mabkhot, Yahia N.
- Abstract
A novel series of bis(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between bis-hydrazonoyl chloride 1 and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the bis-thiadiazole derivatives 5c,d, 7b,c and 9c had higher antitumor activity than the standard drug Imatinib.
- Publication
Molecules, 2016, Vol 21, Issue 11, p1532
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21111532