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- Title
Preparation and In Vitro Evaluation of Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carriers.
- Authors
Yang Chu; Dan Li; Yi-Fan Luo; Xiao-Jin He; Ming-Yan Jiang
- Abstract
Curcumin, a phenolic antioxidant compound derived from the rhizome of the turmeric plant Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer potential. In this study, a Glycyrrhetinic Acid-Modified Curcumin-Loaded Nanostructured Lipid Carrier (Cur-GA-PEG-NLC) was prepared by the film ultrasound method to improve the tumor-targeting ability. The drug content was detected by an UV spectrophotometry method. The encapsulation efficiency of curcumin in the nanostructured lipid carriers (NLCs) was determined using a mini-column centrifugation method. The encapsulation efficiency for various Cur-GA-PEG-NLC was within the range of 90.06%-95.31% and particle size was between 123.1 nm and 132.7 nm. An in vitro MTT assay showed that Cur-GA10%-PEG-NLC had significantly high cellular uptake and cytotoxicity against HepG2 cells compared with other groups.
- Subjects
CURCUMIN; TURMERIC; THERAPEUTIC use of plant extracts; CANCER cell growth; APOPTOSIS; ANTINEOPLASTIC agents
- Publication
Molecules, 2014, Vol 19, Issue 2, p2445
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19022445