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- Title
Isolation and Synthesis of a Bioactive Benzenoid Derivative from the Fruiting Bodies of Antrodia camphorata.
- Authors
Pi-Yu Chen; Jen-Der Wu; Kai-Yih Tang; Chieh-Chou Yu; Yueh-Hsiung Kuo; Wen-Bin Zhong; Ching-Kuo Lee
- Abstract
A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3'- methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus). The structure of antrocamphin O was unambiguously assigned by the analysis of spectral data (including 1D and 2D NMR, high-resolution MS, IR, and UV) and total synthesis. Compound 1 was prepared through the Sonogashira reaction of 5-iodo-4,7-dimethoxy-6-methylbenzene and 2-methylbut-1-en-3-yne as the key step. The benzenoids were tested for cytotoxicity against the HT29, HTC15, DLD-1, and COLO 205 colon cancer cell lines, and activities are reported herein.
- Subjects
POLYCYCLIC aromatic hydrocarbons; FRUITING bodies (Fungi); ANTRODIAETIDAE; ANTIBODY-dependent cell cytotoxicity; CELL lines
- Publication
Molecules, 2013, Vol 18, Issue 7, p7600
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18077600