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- Title
(+)- Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble.
- Authors
Mollataghi, Abbas; Hadi, A. Hamid A.; Awang, Khalijah; Mohamad, Jamaludin; Litaudon, Marc; Mukhtar, Mat Ropi
- Abstract
A new neolignan, 3,4-dimethoxy-3',4'-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC50 of 20.0 μg/mL.
- Subjects
ANTIOXIDANTS; BEILSCHMIEDIA; PHYTOTHERAPY; ALKALOIDS; SPECTRUM analysis; NUCLEAR magnetic resonance
- Publication
Molecules, 2011, Vol 16, Issue 8, p6582
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16086582